Dr. David S. Hoff

Close-up portrait of a middle-aged man with gray hair and a beard, smiling, wearing a blue checkered shirt, in an indoor setting with a softly blurred background.

Chief, Clinical Safety

David Hoff believes a medical system is only as reliable as its safety barriers. He specializes in Structural Reliability—the process of codifying complex clinical data into hard-wired safety protocols that ensure every child receives a "Standard of Excellence." David treats medication safety as a global engineering challenge, focusing on the surgical replacement of unstandardized practices with rigorous, data-driven infrastructure.

In 2017, David addressed a critical "failed state" in pediatrics by commissioning and coordinating the elite task force behind the KIDs List (Key potentially inappropriate drugs in Pediatrics). This groundbreaking document established the first global evidence-based standard for pediatric medication safety, identifying high-risk drugs and excipients to prevent systemic adverse events.

David is a global pioneer in Safety Architecture. His influence extends across international borders, having served as a pharmacy consultant in the Kingdom of Saudi Arabia and in India.

An infographic divided into three columns titled 'Operational & Systemic Impact,' 'Academic Authority,' and 'Scale & Reach.' The first column lists: 6 years of accredited training, 34 years of operational field experience, multi-million dollar budgets, and over 100 systemic protocols authored. The second column lists: 25+ peer-reviewed publications, 500+ citations, five textbook contributions, and a nine H-index score. The third column lists: 25+ national presentations, over 4 million individuals reached via media, work in three countries, and mentoring over 250 clinicians.
Diagram outlining organizational leadership structure and impact in healthcare, featuring key roles like PPA President and Board Chair, and categories such as global clinical impact, clinical advisory roles, credential recognition, and leadership accomplishments.

Academic & Institutional Leadership

  • Pharmacy Director, Acute Care & Clinical Services, Children’s Minnesota.

  • Clinical Associate Professor, University of Minnesota College of Pharmacy.

  • Past-President, Pediatric Pharmacy Association (PPA).

  • Residency Program Director, architecting the next generation of clinical specialists for over a decade.

Clinical & Operational Expertise

  • Board Certified Pediatric Pharmacy Specialist (BCPPS).

  • Pharmacist, Minnesota–1 Disaster Medical Assistance Team (MN–1 DMAT), deployed during federal emergency response operations.

  • Specialist in Lean Leadership, utilizing systems engineering to optimize institutional pharmacy workflows.

National Service and Advocacy

  • Architect of Global Safety Standards: Commissioned and coordinated the development of the KIDs List (Key Potentially Inappropriate Drugs in Pediatrics), transforming pediatric medication safety from institutional preference to a national evidence-based mandate.

  • Served as President and on the Board of Directors of the Pediatric Pharmacy Association (PPA).

  • Federal Emergency Response: Served on the Minnesota–1 Disaster Medical Assistance Team (DMAT).

  • Recipient of the Richard A. Helms Award of Excellence and the Institute for Safe Medication Practices (ISMP) Cheers Award for outstanding national contributions to the science of pediatric medication safety.

National Library of Medicine Publication list
Google Scholar profile
KIDs List of Key Potentially Inappropriate Drugs in Pediatrics